Grape Seed Extract
Scientific Name: Grape Seed Other Names: Muscat, Red Wine Extract, Vitis vinifera
References
Agarwal C, Singh RP, Agarwal R. Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis. 2002;23(11):1869-1876.
Agarwal C, Singh RP, Dhanalakshmi S, Agarwal R. Anti-angiogenic efficacy of grape seed extract in endothelial cells. Oncology Report. 2004;11(3):681-685.
Al-Awwadi NA, Araiz C, Bornet A, et al. Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats. Journal of Agricultural and Food Chemistry. 2005;53(1):151-157.
Anon: Grape seed. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. August 2002.
Ates O, Cayli S, Altinoz E, et al. Neuroprotection by resveratrol against traumatic brain injury in rats. Molecular and Cellular Biochemistry. 2007;294(1-2):137-144.
Auger C, Gerain P, Laurent-Bichon F, et al. Phenolics from Commercialized Grape Extracts Prevent Early Atherosclerotic Lesions in Hamsters by Mechanisms Other than Antioxidant Effect. Journal of Agricultural and Food Chemistry. 2004;52(16):5297-5302.
Baatout S, Derradji H, Jacquet P, Ooms D, Michaux A, Mergeay M. Enhanced radiation-induced apoptosis of cancer cell lines after treatment with resveratrol. International Journal of Molecular Medicine. 2004;13(6):895-902.
Bagchi D, Bagchi M, Stohs S, Ray SD, Sen CK, Preuss HG. Cellular protection with proanthocyanidins derived from grape seeds. Annals of the New York Academy of Sciences. 2002;957:260-270.
Bagchi D, Ray SD, Bagchi M, Preuss HG, Stohs SJ. Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. Indian Journal of Experimental Biology. 2002;40(6):717-726.
Bagchi D, Sen CK, Ray SD, Das DK, Bagchi M, Preuss HG, Vinson JA. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutation Research. 2003;523-524 and 587-597.
Baliga MS, Katiyar SK. Chemoprevention of photocarcinogenesis by selected dietary botanicals. Photochemical and Photobiological Sciences. 2006;5(2):243-253.
Balu M, Sangeetha P, Haripriya D, Panneerselvam C. Rejuvenation of antioxidant system in central nervous system of aged rats by grape seed extract. Neuroscience Letters. 2005;383(3):295-300.
Balu M, Sangeetha P, Murali G, Panneerselvam C. Age-related oxidative protein damages in central nervous system of rats: modulatory role of grape seed extract. International Journal of Developmental Neuroscience. 2005;23(6):501-507.
Barden CA, Chandler HL, Lu P, Bomser JA, Colitz CM. Effect of grape polyphenols on oxidative stress in canine lens epithelial cells. American Journal of Veterinary Research. 2008;69(1):94-100.
Barger JL, Kayo T, Vann JM, et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE. 2008;3(6):e2264. Available at: http://www.plosone.org/article/info%3Adoi%2F10.1371 %2Fjournal.pone.0002264. Accessed June 5, 2008.
Bentivegna SS, Whitney KM. Subchronic 3-month oral toxicity study of grape seed and grape skin extracts. Food Chemistry and Toxicology. 2002;40(12):1731-1743.
Bhat KP, Pezzuto JM. Cancer chemopreventive activity of resveratrol. Annals of the New York Academy of Sciences. 2002;957:210-229.
Bruno R, Ghisolfi L, Priulla M, Nicolin A, Bertelli A. Wine and tumors: study of resveratrol. Drugs under Experimental and Clinical Research. 2003;29(5-6):257-261.
Busserolles J, Gueux E, Balasinska B, et al. In vivo antioxidant activity of procyanidin-rich extracts from grape seed and pine (Pinus maritima) bark in rats. International Journal of Vitamins and Nutrition Research. 2006;76(1):22-27.
Cao Z, Fang J, Xia C, Shi X, Jiang BH. trans-3,4,5'-Trihydroxystibene Inhibits Hypoxia-Inducible Factor 1{alpha} and Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells. Clinical Cancer Research. 2004;10(15):5253-5263.
Cao Z, Li Y. Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury. European Journal of Pharmacology. 2004;489(1-2):39-48.
Chen Y, Tseng SH, Lai HS, Chen WJ. Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice. Surgery. 2004;136(1):57-66.
Cheng M, Gao HQ, Xu L, Li BY, Zhang H, Li XH. Cardioprotective effects of grape seed proanthocyanidins extracts in streptozocin induced diabetic rats. Journal of Cardiovascular Pharmacology. 2007;50(5):503-509.
Devi A, Jolitha AB, Ishii N. Grape Seed Proanthocyanidin Extract (GSPE) and antioxidant defense in the brain of adult rats. Medical Science Monitor. 2006;12(4):BR124-129.
Dhanalakshmi S, Agarwal R, Agarwal C. Inhibition of NF-kappaB pathway in grape seed extract-induced apoptotic death of human prostate carcinoma DU145 cells. International Journal of Oncology. 2003;23(3):721-727.
Donnelly LE, Newton R, Kennedy GE, Fenwick PS, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. American Journal of Physiology and Lung Cell Molecular Physiology. 2004;287(4):L774-L783.
Du Y, Guo H, Lou H. Grape seed polyphenols protect cardiac cells from apoptosis via induction of endogenous antioxidant enzymes. Journal of Agricultural and Food Chemistry. 2007;55(5):1695-1701.
Dulak J. Nutraceuticals as anti-angiogenic agents: hopes and reality. Journal of Physiology and Pharmacology. 2005;56(Suppl 1):51-69.
Dulundu E, Ozel Y, Topaloglu U, et al. Grape seed extract reduces oxidative stress and fibrosis in experimental biliary obstruction. Journal of Gastroenterology and Hepatology. 2007;22(6):885-892.
Durak I, Cetin R, Candir O, Devrim E, Kilicoglu B, Avci A. Black grape and garlic extracts protect against cyclosporine a nephrotoxicity. Immunology Investigations. 2007;36(1):105-114.
Durukan AH, Evereklioglu C, Hurmeric V, et al. Ingestion of IH636 grape seed proanthocyanidin extract to prevent selenite-induced oxidative stress in experimental cataract. Journal of Cataract and Refractive Surgery. 2006;32(6):1041-1045.
Edirisinghe I, Burton-Freeman B, Tissa Kappagoda C. Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clinical Sciences (London). 2008;114(4):331-337.
El-Alfy AT, Ahmed AA, Fatani AJ. Protective effect of red grape seeds proanthocyanidins against induction of diabetes by alloxan in rats. Pharmacology Research. 2005;52(3):264-270.
El-Alfy AT, Ahmed AA, Fatani AJ, Kader F. Amelioration of the cardiovascular manifestations of the yellow scorpion Leiurus quinquestriatus envenomation in rats by red grape seeds proanthocyanidins. Toxicon. 2008;51(3):321-333.
El-Ashmawy IM, El-Nahas AF, Salama OM. Grape seed extract prevents gentamicin-induced nephrotoxicity and genotoxicity in bone marrow cells of mice. Basic Clinical Pharmacology and Toxicology. 2006 ;99(3):230-236.
Eng ET, Ye J, Williams D, et al. Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds. Cancer Research. 2003;63(23):8516-8522.
El-Ashmawy IM, Saleh A, Salama OM. Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats. Basic Clinical Pharmacology and Toxicology. 2007;101(5):320-327.
Eng ET, Ye J, Williams D, et al. Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds. Cancer Research. 2003;63(23):8516-8522.
Enginar H, Cemek M, Karaca T, Unak P. Effect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to x-radiation. Phytotherapy Research. 2007;21(11):1029-1035.
Erexson GL. Lack of in vivo clastogenic activity of grape seed and grape skin extracts in a mouse micronucleus assay. Food Chemistry and Toxicology. 2003;41(3):347-350.
Etheridge AS, Black SR, Patel PR, So J, Mathews JM. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Medica. 2007;73(8):731-741.
Evers DL, Wang X, Huong SM, Huang DY, Huang ES. 3,4',5-Trihydroxy-trans-stilbene (resveratrol) inhibits human cytomegalovirus replication and virus-induced cellular signaling. Antiviral Research. 2004;63(2):85-95.
Falchetti R, Fuggetta MP, Lanzilli G, Tricarico M, Ravagnan G. Effects of resveratrol on human immune cell function. Life Sciences. 2001;70(1):81-96.
Feng Y, Liu YM, Leblanc MH, Bhatt AJ, Rhodes PG. Grape seed extract given three hours after injury suppresses lipid peroxidation and reduces hypoxic-ischemic brain injury in neonatal rats. Pediatric Research. 2007;61(3):295-300.
Fitzpatrick DF, Bing B, Maggi DA, Fleming RC, O'Malley RM. Vasodilating procyanidins derived from grape seeds.
Annals of the New York Academy of Sciences. 2002;957:78-89.
Frederiksen H, Mortensen A, Schroder M, et al. Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits. Molecular Nutrition and Food Research. 2007;51(5):564-571.
Fu ZD, Cao Y, Wang KF, Xu SF, Han R. Chemopreventive effect of resveratrol to cancer. [Article in Chinese] Ai Zheng. 2004;23(8):869-873.
Fujii H, Yokozawa T, Kim YA, Tohda C, Nonaka G. Protective effect of grape seed polyphenols against high glucose-induced oxidative stress. Bioscience, Biotechnology and Biochemistry. 2006;70(9):2104-2111.
Fulda S, Debatin KM. Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol. Oncogene. 2004;23(40):6702-6711.
Gao X, Deeb D, Media J, Divine G, Jiang H, Chapman RA, Gautam SC. Immunomodulatory activity of resveratrol: discrepant in vitro and in vivo immunological effects. Biochemistry and Pharmacology. 2003;66(12):2427-2435.
Gao S, Liu GZ, Wang Z. Modulation of androgen receptor-dependent transcription by resveratrol and genistein in prostate cancer cells. Prostate. 2004;59(2):214-225.
Gehm BD, Levenson AS, Liu H, et al. Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2. Journal of Steroid Biochemistry and Molecular Biology. 2004;88(3):223-234.
Guo L, Wang LH, Sun B, et al. Direct in vivo evidence of protective effects of grape seed procyanidin fractions and other antioxidants against ethanol-induced oxidative DNA damage in mouse brain cells. Journal of Agricultural and Food Chemistry. 2007;55(14):5881-5891.
Han Y. Synergic effect of grape seed extract with amphotericin B against disseminated candidiasis due to Candida albicans. Phytomedicine. 2007;14(11):733-738.
Heredia A, Davis C, Redfield R. Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol. Journal of Acquired Immune Deficiency Syndrome. 2000;25(3):246-255.
Hudson TS, Hartle DK, Hursting SD, et al. Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms. Cancer Research. 2007;67(17):8396-8405.
International Programme [sic] on Chemical Safety. Environmental health criteria 119. Principles and methods for the assessment of nephrotoxicity associated with exposure to chemicals. 1991. Available at: http://www.inchem.org/documents/ehc/ehc/ehc119.htm# SubSectionNumber:2.5.2. Accessed April 13, 2007.
Jazirehi AR, Bonavida B. Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Molecular Cancer Therapy. 2004;3(1):71-84.
Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.
Joshi SS, Kuszynski CA, Bagchi D. The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract. Current Pharmaceuticals and Biotechnology. 2001;2(2):187-200.
Joshi SS, Kuszynski CA, Bagchi M, Bagchi D. Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells. Toxicology. 2000;155(1-3):83-90.
Kang JH, Park YH, Choi SW, Yang EK, Lee WJ. Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells. Experimental and Molecular Medicine. 2003;35(6):467-474.
Karthikeyan K, Bai BR, Devaraj SN. Cardioprotective effect of grape seed proanthocyanidins on isoproterenol-induced myocardial injury in rats. International Journal of Cardiology. 2007;115(3):326-333.
Karthikeyan K, Sarala Bai BR, Niranjali Devaraj S. Grape seed proanthocyanidins ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes: an in vivo study. Life Sciences. 2007;81(23-24):1615-1621.
Katiyar SK. Grape seed proanthocyanidines and skin cancer prevention: Inhibition of oxidative stress and protection of immune system. Molecular Nutrition and Food Research. Epublished ahead of print. April 2, 2008.
Katiyar SK. Matrix metalloproteinases in cancer metastasis: molecular targets for prostate cancer prevention by green tea polyphenols and grape seed proanthocyanidins. Endocr Metab Immune Disord Drug Targets. 2006;6(1):17-24.
Katiyar SK. UV-induced immune suppression and photocarcinogenesis: Chemoprevention by dietary botanical agents. Cancer Letter. 2007;255(1):1-11.
Kaur M, Singh RP, Gu M, Agarwal R, Agarwal C. Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clinical Cancer Research. 2006;12(20 Pt 1):6194-6202.
Khanna S, Venojarvi M, Roy S, et al. Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radical Biology and Medicine. 2002 Oct;33(8):1089-1096.
Kijima I, Phung S, Hur G, Kwok SL, Chen S. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Research. 2006;66(11):5960-5967.
Kim YA, Choi BT, Lee YT, et al. Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncology Report. 2004;11(2):441-446.
Kim YA, Rhee SH, Park KY, Choi YH. Antiproliferative effect of resveratrol in human prostate carcinoma cells. Journal of Medicinal Foods. 2003;6(4):273-280.
Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL, for the Nutrition Committee of the American Heart Association Council on Nutrition, Physical Activity, and Metabolism. Antioxidant vitamin supplements and cardiovascular disease. Circulation. 2004;110(5):637-641.
Laux MT, Aregullin M, Berry JP, Flanders JA, Rodriguez E. Identification of a p53-dependent pathway in the induction of apoptosis of human breast cancer cells by the natural product, resveratrol. Journal of Alternative Complementary Medicine. 2004;10(2):235-239.
Li BY, Cheng M, Gao HQ, et al. Back-regulation of six oxidative stress proteins with grape seed proanthocyanidin extracts in rat diabetic nephropathy. Journal of Cellular Biochemistry. Epublished ahead of print. January 7, 2008.
Liu YN, Shen XN, Yao GY. Effects of grape seed proanthocyanidins extracts on experimental diabetic nephropathy in rats. {Article in Chinese] Wei Sheng Yan Jiu. 2006;35(6):703-705.
Mantena SK, Baliga MS, Katiyar SK. Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis. 2006;27(8):1682-1691.
Mantena SK, Katiyar SK. Grape seed proanthocyanidins inhibit UV-radiation-induced oxidative stress and activation of MAPK and NF-kappaB signaling in human epidermal keratinocytes. Free Radical Biology and Medicine. 2006;40(9):1603-1614.
Martinez MJ, Bonfill X, Moreno RM, Vargas E, Capella D. Phlebotonics for venous insufficiency. Cochrane Database Systematic Review. 2005;(3):CD003229.
Mattoo TK, Kovacevic L. Effect of grape seed extract on puromycin-aminonucleoside-induced nephrosis in rats. Pediatric Nephrology. 2003;18(9):872-877.
McDougall GJ, Shpiro F, Dobson P, Smith P, Blake A, Stewart D. Different polyphenolic components of soft fruits inhibit alpha-amylase and alpha-glucosidase. Journal of Agricultural and Food Chemistry. 2005;53(7):2760-2766.
McElderry, MQB. Grape expectations: the resveratrol story. QuackWatch. Updated September 1, 1999. Available at: http://www.quackwatch.org/01QuackeryRelatedTopics/D SH/resveratrol.html. Accessed September 27, 2004.
Meeran SM, Katiyar SK. Proanthocyanidins inhibit mitogenic and survival-signaling in vitro and tumor growth in vivo. Frontiers in Bioscience. 2008;13:887-897.
Mohanasundari M, Sabesan M, Sethupathy S. Renoprotective effect of grape seeds extract in ethylene glycol induced nephrotoxic mice. Indian Journal of Experimental Biology. 2005;43(4):356-359.
Moreno DA, Ilic N, Poulev A, Brasaemle DL, Fried SK, Raskin I. Inhibitory effects of grape seed extract on lipases. Nutrition. 2003 Oct;19(10):876-879.
Morre DM, Morre DJ. Anticancer activity of grape and grape skin extracts alone and combined with green tea infusions. Cancer Letters. 2006;238(2):202-209.
Nair MP, Kandaswami C, Mahajan S, et al. Grape seed extract proanthocyanidins downregulate HIV-1 entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheral blood mononuclear cells. Biological Research. 2002;35(3-4):421-431.
Natella F, Belelli F, Gentili V, Ursini F, Scaccini C. Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. Journal of Agricultural and Food Chemistry. 2002;50(26):7720-7725.
Natural Medicines Comprehensive Database, Online Edition. Pharmacist's Letter/Prescriber's Letter. Stockton CA: Therapeutic Research Facility, 2006.
Available at: http://www.pharmacistsletter.com/(S(ulqz3s45omt3ag5 5um4kj345))/home.aspx?li=1&st=1&cs=&s=ND.
Nikitina NA, Sobenin IA, Myasoedova VA, et al. Antiatherogenic effect of grape flavonoids in an ex vivo model. Bulletin of Experimental Biology and Medicine. 2006;141(6):712715.
Olas B, Wachowicz B, Bald E, Glowacki R. The protective effects of resveratrol against changes in blood platelet thiols induced by platinum compounds. Journal of Physiology and Pharmacology. 2004;55(2):467-476.
Olas B, Wachowicz B, Tomczak A, Erler J, Stochmal A, Oleszek W. Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Platelets. 2008;19(1):70-77.
Opipari AW Jr, Tan L, Boitano AE, Sorenson DR, Aurora A, Liu JR. Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Research. 2004;64(2):696-703.
PDR Health. Grape seed proanthocyanidins. No date given. Available at: http://www.pdrhealth.com/drug_info/nmdrugprofiles/n utsupdrugs/gra_0129.shtml. Accessed September 29, 2004.
Peng N, Clark JT, Prasain J, Kim H, White CR, Wyss JM. Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. American Journal of Physiology Regulatory, Integrative and Comparative Physiology. 2005 Sep;289(3):R771-R775.
Pinent M, Blay M, Blade MC, Salvado MJ, Arola L, Ardevol A. Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology. 2004;145(11):4985-4990.
Polagruto JA, Gross HB, Kamangar F, et al. Platelet reactivity in male smokers following the acute consumption of a flavanol-rich grapeseed [sic] extract. Journal of Medicinal Food. 2007;10(4):725-730.
Preuss HG, Montamarry S, Echard B, Scheckenbach R, Bagchi D. Long-term effects of chromium, grape seed extract, and zinc on various metabolic parameters of rats. Molecular and Cellular Biochemistry. 2001;223(1-2):95-102.
Sangeetha P, Balu M, Haripriya D, Panneerselvam C. Age associated changes in erythrocyte membrane surface charge: Modulatory role of grape seed proanthocyanidins. Experimental Gerontology. 2005;40(10):820-828.
Sano T, Oda E, Yamashita T, et al. Anti-thrombotic effect of proanthocyanidin, a purified ingredient of grape seed. Thrombosis Research. 2005;115(1-2):115-121.
Sano A, Uchida R, Saito M, et al. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. Journal of Nutritional Science and Vitaminology (Tokyo). 2007;53(2):174-182.
Savaskan E, Olivieri G, Meier F, Seifritz E, Wirz-Justice A, Muller-Spahn F. Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity. Gerontology. 2003;49(6):380-383.
Shafiee M, Carbonneau MA, Urban N, Descomps B, Leger CL. Grape and grape seed extract capacities at protecting LDL against oxidation generated by Cu2+, AAPH or SIN-1 and at decreasing superoxide THP-1 cell production. A comparison to other extracts or compounds. Free Radical Research. 2003;37(5):573-584.
Shanmuganayagam D, Beahm MR, Osman HE, Krueger CG, Reed JD, Folts JD. Grape seed and grape skin extracts elicit a greater antiplatelet effect when used in combination than when used individually in dogs and humans. Journal of Nutrition. 2002;132(12):3592-3598.
Shao ZH, Hsu CW, Chang WT, et al. Cytotoxicity induced by grape seed proanthocyanidins: Role of nitric oxide. Cell Biology and Toxicology. 2006;22(3):149-158.
Shao ZH, Vanden Hoek TL, Li CQ, et al. Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro. American Journal of Chinese Medicine. 2004;32(1):89-95.
Shao ZH, Vanden Hoek TL, Xie J, et al. Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes. Cardiovascular Toxicology. 2003;3(4):331-339.
Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Research and Treatment. 2004;85(1):1-12.
Sharma SD, Meeran SM, Katiyar SK. Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-kappaB signaling in in vivo SKH-1 hairless mice. Molecular Cancer Therapy. 2007;6(3):995-1005.
Shi J, Yu J, Pohorly JE, Kakuda Y. Polyphenolics in grape seeds-biochemistry and functionality. Journal of Medicinal Foods. 2003;6(4):291-299.
Simonetti P, Ciappellano S, Gardana C, Bramati L, Pietta P. Procyanidins from Vitis vinifera seeds: in vivo effects on oxidative stress. Journal of Agricultural and Food Chemistry. 2002;50(21):6217-6221.
Singh RP, Agarwal R. Mechanisms of action of novel agents for prostate cancer chemoprevention. Endocrine Related Cancer. 2006;13(3):751-778.
Singh RP, Tyagi AK, Dhanalakshmi S, Agarwal R, Agarwal C. Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. International Journal of Cancer. 2004;108(5):7337-40.
Sirtris receives orphan drug designation from U.S. Food and Drug Administration for resveratrol in mitochondrial disorder, MELAS Syndrome [press release]. Cambridge, MA: Sirtris Pharmaceuticals; April 2, 2008. Available at: http://phx.corporate-ir.net/phoenix.zhtml?c=185399& p=irol-newsArticle&ID=1124691&highlight=. Accessed April 14, 2008.
Tribble DL, for the Nutrition Committee of the American Heart Association Council on Nutrition, Physical Activity, and Metabolism. Antioxidant consumption and risk of coronary heart disease. Circulation. 1999;99:591-595.
Uchida S, Hirai K, Hatanaka J, Hanato J, Umegaki K, Yamada S. Antinociceptive effects of St. John's wort, Harpagophytum procumbens extract and Grape seed proanthocyanidins extract in mice. Biology and Pharmacy Bulletin. 2008;31(2):240-245.
Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE. Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. Journal of Cardiovascular Pharmacology. 2005 Oct;46(4):445-551.
Vogels N, Nijs IM, Westerterp-Plantenga MS. The effect of grape-seed extract on 24 h energy intake in humans. European Journal of Clinical Nutrition. 2004;58(4):667-673.
Wang LX, Heredia A, Song H, et al. Resveratrol glucuronides as the metabolites of resveratrol in humans: Characterization, synthesis, and anti-HIV activity. Journal of Pharmaceutical Sciences. 2004;93(10):2448-2457.
Ward NC, Hodgson JM, Croft KD, Burke V, Beilin LJ, Puddey IB. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. Journal of Hypertension. 2005;23(2):427-434.
Weber HA, Hodges AE, Guthrie JR, et al. Comparison of proanthocyanidins in commercial antioxidants: grape seed and pine bark extracts. Journal of Agricultural and Food Chemistry. 2007 Jan 10;55(1):148-56.
Wren AF, Cleary M, Frantz C, Melton S, Norris L. 90-day oral toxicity study of a grape seed extract (IH636) in rats. Journal of Agricultural and Food Chemistry. 2002;50(7):2180-2192.
Xu L, Li B, Cheng M, et al. Oral administration of grape seed proanthocyanidin extracts downregulate RAGE dependant nuclear factor- kappa bp65 expression in the hippocampus of streptozotocin induced diabetic rats. Experimental and Clinical Endocrinology in Diabetes. 2008;116(4):215-224.
Yamakoshi J, Saito M, Kataoka S, Kikuchi M. Safety evaluation of proanthocyanidin-rich extract from grape seeds. Food Chemistry and Toxicology. 2002;40(5):599-607.
Yamakoshi J, Saito M, Kataoka S, Tokutake S. Procyanidin-rich extract from grape seeds prevents cataract formation in hereditary cataractous (ICR/f) rats.
Journal of Agricultural and Food Chemistry. 2002;50(17):4983-4988.
Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW. Modulation of NF-B-dependent transcription and cell survival by the SIRT1 deacetylase. European Molecular Biology Organization Journal. 2004;23(10):2369-2380.
Zhang S, Cao HJ, Davis FB, Tang HY, Davis PJ, Lin HY. Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells. British Journal of Cancer. 2004;91(1):178-185.
Zhang XY, Li WG, Wu YJ, et al. Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism. International Immunopharmacology. 2005;5(7-8):1247-1257.
Last Revised April 14, 2008
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